The Heart of the Matter
Jane Grand-Allen ’91 Jane Grande-Allen ’91, who graduated from Transylvania with majors in biology and mathematics, began studying heart valves when she started her Ph.D. research at the University of Washington in Seattle. At the time, the majority of the research being done was focused on improving replacement heart valves instead of the disease itself and possible treatments or cures. “That kind of stifled study into what causes valve disease because the (replacement valve) surgeons are excellent, and the replacements are awfully good,” Grande-Allen said. “So they weren’t really asking, ‘How can we prevent this disease in the first place?’” But Grande-Allen did ask that question. Even though replacement heart valves have become so effective, the surgery is still invasive—although work is being done to begin widely implanting them in a non surgical manner with a stent—and finding treatments for valve diseases remains an appealing goal. That’s why she has spent all this time on just that problem. “We’re trying to improve the range of options for treating people with heart valve disease,” she said. “Some of my work is targeted to helping find new medications so people could just take some pills instead of having to have surgery.” She credits her Transylvania professors for steering her in this direction, like former mathematics professor David Shannon. “He was my mentor when I was at Transylvania, and he really impressed upon me that I should continue doing something that had a
