1780 Transylvania Seminary, the pioneer institution of higher learning west of the Alleghenies, is established and supported by Virginia Governor Thomas Jefferson.
1793 A gift of land, then called the College Lot and now known as Gratz Park, is accepted by Transylvania trustees in return for a promise to relocate and maintain the campus in Lexington.
1799 Transylvania—the university—is established, creating the first law school and medical school in the West, pursuant to Kentucky legislature's charter amendment.
1805 Statesman, Speaker of the House, and five-time presidential candidate Henry Clay is appointed professor of law.
1807 Henry Clay is named to the board of trustees, a position he retains whenever he is in Kentucky, remaining a friend of the university until his death in 1852.
1818 Horace Holley, a Unitarian minister from Boston, is recruited as the third president of the university. His influence and connections in the east—including several U.S. presidents, congressmen, and representatives—help raise Transylvania's national profile considerably. Enrollment increases and professors are sent to Europe to procure texts and tools for the medical and law departments. The medical school soon rivals Harvard's.
1820 Kappa Lamda of Hippocrates, the first medical fraternity of its kind, is founded by professor Samuel Brown at Transylvania. Branches of the society ultimately lead to the founding of the American Medical Association.
1833 Old Morrison, today Transylvania's administration building, is built to replace an earlier building on the College Lot destroyed by fire.
1834 Transylvania's Law Department becomes one of the most distinguished in the nation as a result of George Robertson, Chief Justice of the Kentucky Court of Appeals, joining the faculty. It and the Medical Department graduate a number of notable Americans in the pre-Civil War era, including future justices of the United States Supreme Court, Samuel Freeman Miller and John Marshall Harlan.
1859 After training over 6,000 students to become physicians, Transylvania's Medical Department closes.
1861 The Civil War interrupts instruction at Transylvania. Old Morrison and the medical building are turned into makeshift hospitals for Union troops.
1865 Transylvania University merges with Kentucky University in Harrodsburg, formerly called Bacon College. The name Kentucky University is used until 1908. During this time the university expands and several new departments materialize, including the College of Arts and Sciences and the Agricultural and Mechanical College.
1880 The first recorded intercollegiate football game in the south is played: Kentucky University (Transylvania) vs. Centre College, with K.U. ousting Centre 13.75 to 0.
1889 Co-education begins, with Kate Van Arsdall becoming the first female graduate four years later.
1908 Kentucky University's Agricultural and Mechanical College becomes the state's land grant university, the University of Kentucky, while the remaining parts are renamed Transylvania University.
1911 The University of Kentucky beats Transylvania 30-24 in basketball on the Wildcats' home court, evening the all-time series at 7-7. The rivalry would be renewed 100 years later on November 11, 2011, in an exhibition game at Rupp Arena in Lexington, with UK breaking the tie in a 97-53 win.
1924 The body of nineteenth-century professor Samuel Constantine Rafinesque is brought back from an unmarked grave in Philadelphia to rest in a tomb in Old Morrison.
1954 President Dwight D. Eisenhower speaks at Transylvania's 175th anniversary celebration and dedication of the Frances Carrick Thomas Library.
1982 The William T. Young scholarship program is established, providing merit scholarships covering tuition and general fees for 20-25 entering students each year. Formerly named the Jefferson Scholars program after the founding father who was governor of Virginia when Transylvania was founded, it is renamed for Transylvania's principal supporter.
1984 Vice President George H. Bush dedicates the J. Douglas Gay Jr. addition to the Frances Carrick Thomas Library.
1985 The William R. Kenan lecture series is established to bring nationally known speakers to campus. Speakers have included Elie Wiesel, Kurt Vonnegut, John Updike, and Beverly Sills, among others.
1996 Lucille Caudill Little donates $1 million toward the construction of a performing arts center. The new home of the theater department is a black box-style theater with a grid lighting system.
2002 The Clive M. Beck Center is dedicated, housing the university's recreation and athletic facilities.
2004 Transylvania joins the National Collegiate Athletic Association, Division III.
2006 Transylvania hosts the first annual faculty seminar on liberal education, Twenty-first Century Liberal Education: A Contested Concept.
2007 Dorothy J. Smith '42 creates the Dorothy J. and Fred K. Smith Endowed Concert Series and the Sharon Sue Smith Memorial Scholarship, to enrich the cultural and academic musical environment at Transylvania. The concert series has brought acts such as the Kronos Quartet, Chanticleer, and Tiempo Libre to campus.
2008 Thomson Residence Hall opens. In 2009, it becomes the first residence hall in Kentucky to earn the U.S. Environmental Protection Agency's prestigious ENERGY STAR certification for superior energy efficiency and environmental protection.
2008 Bill and Hillary Clinton both speak at a Get Out the Vote Rally in the Beck Center.
2010 Charles L. Shearer, the longest serving Transylvania president, retires after 27 years. Under his tenure the university saw a 76 percent increase in enrollment and a 339 percent increase in the endowment from 1983 to its all-time high in 2007.
2010 R. Owen Williams becomes the 25th president.
2011 The Harlan Lecture Series is established, named after 1852 Transylvania graduate and United States Supreme Court Justice John Marshall Harlan. William Wiecek, legal and constitutional historian and professor of public law and legislation at Syracuse University, will give the inaugural Harlan Lecture on September 26, followed by a spring 2012 lecture presented by Akhil Reed Amar, professor of law and political science at Yale University.
2011 Speaker of the House John Boehner and former Speakers Nancy Pelosi and Dennis Hastert speak in Haggin Auditorium at an event recognizing the 200th anniversary of Henry Clay's election as Speaker of the House. The discussion was moderated by John Harwood of CNBC and The New York Times.